Endocannabinoid System and CBD

New finding: coffee has the opposite effect on marijuana

Coffee is a type of beverage that is now easy to find anywhere. Many people love this one drink. The study, published in the Journal of Internal Medicine, found that coffee caused lower levels of endocannabinoids endocannabinoid system and CBD, a substance that is linked to the body’s system for responding to marijuana.

The researchers found that people who drank between 4-8 cups of coffee a day had decreased endocannabinoids. Endocannabinoids are molecules that bind to cannabinoid receptors (an active ingredient in marijuana), which are found throughout the nervous system, as well as in immune and endocrine tissues.

The human body makes its endocannabinoids. But the body also responds to foreign cannabinoids, such as those found in the leaves of the plant genus Cannabis.

Marilyn Cornelis, leader of the study, said that coffee suppresses these chemicals, preventing someone from smoking marijuana. Cornelis also explained that coffee can produce the opposite effect of marijuana on the endocannabinoid system.

To note, this study did not look at the sensations or behavior that resulted from consuming coffee or marijuana, but the researchers only looked at the ups and downs of substances in the body after consuming these two objects.

Cornelis added, this means drinking coffee with marijuana on your system can create an interacting effect even though the nature of the interaction is not clear.

According to Cornelis, the endocannabinoid base that decreases with coffee consumption also decreases when the body is stressed. It is possible that the amount of coffee consumed by the study participants (4-8 cups a day) caused stress on the body.
This is what is thought to be the cause of the drop in endocannabinoid levels.

Also, Cornelis and his team found that coffee consumption increases the concentration of steroids in the blood. This may be because coffee contains plant steroids called phytosterols.
This study also found that coffee consumption was associated with changes in about 115 substances in the blood. As many as 34 of them do not have a name and their role in the body is unknown.